ABSTRACT
Abstract Objective: To investigate the optimal timing of initial intravenous immunoglobulin (IVIG) treatment in Kawasaki disease (KD) patients. Methods: KD patients were classified as the early group (day 1-4), conventional group (day 5-7), conventional group (day 8-10), and late group (after day 10). Differences among the groups were analyzed by ANOVA and Chi-square analysis. Predictors of IVIG resistance and the optimal cut-off value were determined by multiple logistic regression analyses and receiver operating characteristic (ROC) curve analysis. Results: There were no significant differences in IVIG resistance among the 4 groups (p = 0.335). The sensitivity analysis also confirmed no difference in the IVIG resistance between those who started the initial IVIG ≤ day 7 of illness and those who received IVIG >day 7 of illness (p = 0.761). In addition, patients who received IVIG administration more than 7 days from the onset had a higher proportion of coronary artery abnormalities (p = 0.034) and longer length of hospitalization (p = 0.033) than those who started IVIG administration less than 7 days. The optimal cut-off value of initial IVIG administration time for predicting IVIG resistance was >7 days, with a sensitivity of 75.25% and specificity of 82.41%. Conclusions: IVIG therapy within 7 days of illness is found to be more effective for reducing the risk of coronary artery abnormalities than those who received IVIG >day 7 of illness. IVIG treatment within the 7 days of illness seems to be the optimal therapeutic window of IVIG. However, further prospective studies with long-term follow-up are required.
ABSTRACT
Objective @#To compare the bacteriostatic effect of two disinfections on the surface of frequently touched objects in dental clinic, so as to provide the reference for proper disinfection.@*Methods @#Specimens from the control panel and surface of examination table of comprehensive treatment chair were taken for bacterial culture, record the bacteria content on the objects surface. Then disinfect the objects surface by using 500 mg/L chlorine-containing disinfectant (routing group) and Gamma disinfecting wet wipes (test group) respectively, compare the qualified rate of bacteriostasis on object surfaces between two group. @*Results @# After 10-minute disinfection on surfaces, bacteriostatic rate of routing group and test group was (91.66 ± 7.52)% and (93.87 ± 6.12)% respectively, there was no significant difference between two groups (P > 0.05).@*Conclusion@#The quaternary ammonium disinfectant for the dental clinic objects can reach the same effect as chlorine-containing disinfectant.